Relações entre Preditores da Síndrome Metabólica, Aptidão Aeróbica e Estresse Oxidativo em Militares do Exército Brasileiro

Marcio Antonio de Barros Sena; Paula Fernandez Ferreira; Renan Muniz dos  Santos; Marco de Sá Rego Fortes; Danielli Braga de Mello; Samir Ezequiel  Da Rosa; Marcos Dias Pereira

doi:10.70545/ran.v9i14.13035

Authors

Marcio Antonio de Barros Sena Instituto de Pesquisa da Capacitação Física do Exército - IPCFEx https://orcid.org/0000-0003-4671-5100
Paula Fernandez Ferreira Instituto de Pesquisa da Capacitação Física do Exército - IPCFEx https://orcid.org/0000-0003-3742-1549
Renan Muniz dos Santos Gaffrée e Guinle University Hospital https://orcid.org/0000-0002-3960-5299
Marco de Sá Rego Fortes Instituto de Pesquisa da Capacitação Física do Exército - IPCFEx https://orcid.org/0000-0003-2038-5545
Danielli Braga de Mello Escola de Educação Física do Exército - EsEFEx https://orcid.org/0000-0003-3609-0004
Samir Ezequiel Da Rosa Instituto de Pesquisa da Capacitação Física do Exército - IPCFEx https://orcid.org/0000-0003-3355-0626
Marcos Dias Pereira Universidade Federal do Rio de Janeiro - UFRJ https://orcid.org/0000-0001-5594-2255

DOI:

https://doi.org/10.70545/ran.v9i14.13035

Keywords:

Military Personnel, Metabolic Syndrome, Oxidative Stress, Aerobic Fitness, Anthropometric Parameters

Abstract

Military personnel are deployed in situations requiring operational readiness, and for this, they must maintain a high level of physical fitness. This study assessed the prevalence of metabolic syndrome (MS) and its relationship with anthropometric parameters, oxidative stress, and cardiorespiratory fitness in Brazilian Army military personnel. The study included 83 individuals (aged 35 to 45) who were students at a Brazilian Army specialization school. Participants were divided into two groups based on the results of a 12-minute run test: "good" cardiorespiratory fitness level (n=20) and "excellent" (n=63). Blood samples (serum) were collected after a 12-hour fast for the analysis of MS markers and oxidative stress. Anthropometric parameters, body composition, and physiological metrics were analyzed using standard protocols. Maximum oxygen volume levels (VO2max) were obtained from the 12-minute run test (Cooper test). The "excellent" group showed a 12% prevalence of MS, compared to 20% in the "good" group. Additionally, the "excellent" group demonstrated better levels in almost all markers studied compared to the "good" group, with VO2max being 1,7 times higher in the "excellent" group. The results indicate that higher VO2max levels are associated with a reduced cardiovascular risk, particularly by promoting better aerobic fitness, total antioxidant activity, and a healthier metabolic profile, which consequently contributes to the health and readiness of military personnel.

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AMAWI, A.; ALKASASBEH, W.; JARADAT, M.; ALMASRI, A. et al. Athletes' nutritional demands: a narrative review of nutritional requirements. Front Nutr, 10, p. 1331854, 2023. Disponível em: 10.3389/fnut.2023.1331854.

AMIN, M.; KERR, D.; ATIASE, Y.; ALDWIKAT, R. K. et al. Effect of Physical Activity on Metabolic Syndrome Markers in Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Sports (Basel), 11, n. 5, May 09 2023. Disponível em: 10.3390/sports11050101.

ASTORINO, T. A.; EDMUNDS, R. M.; CLARK, A.; KING, L. et al. Increased cardiac output and maximal oxygen uptake in response to ten sessions of high intensity interval training. J Sports Med Phys Fitness, 58, n. 1-2, p. 164-171, 2018. Disponível em: 10.23736/S0022-4707.16.06606-8.

AYALA, A.; MUÑOZ, M. F.; ARGÜELLES, S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev, 2014, p. 360438, 2014. Disponível em: 10.1155/2014/360438.

BARRÓN-CABRERA, E.; RAMOS-LOPEZ, O.; GONZÁLEZ-BECERRA, K.; RIEZU-BOJ, J. I. et al. Epigenetic Modifications as Outcomes of Exercise Interventions Related to Specific Metabolic Alterations: A Systematic Review. Lifestyle Genom, 12, n. 1-6, p. 25-44, 2019. Disponível em: 10.1159/000503289.

BASSINI, A.; CAMERON, L. C. Sportomics: building a new concept in metabolic studies and exercise science. Biochem Biophys Res Commun, 445, n. 4, p. 708-716, Mar 21 2014. Disponível em: 10.1016/j.bbrc.2013.12.137.

BRAND-WILLIAMS, W.; CUVELIER, M. E.; BERSET, C. Use of a free radical method to evaluate antioxidant activity. LWT - Food Science and Technology, 28, n. 1, p. 25-30, 1995. Disponível em: 10.1016/S0023-6438(95)80008-5.

CARRIER, A. Metabolic Syndrome and Oxidative Stress: A Complex Relationship. Antioxid Redox Signal, 26, n. 9, p. 429-431, Mar 20 2017. Disponível em: 10.1089/ars.2016.6929.

.CEPPA, F.; MERENS, A.; BURNAT, P.; MAYAUDON, H. et al. Military community: a privileged site for clinical research: Epidemiological Study of Metabolic Syndrome Risk Factors in the Military Environment. Mil Med, 173, n. 10, p. 960-967, Oct 2008. Disponível em: 10.7205/milmed.173.10.960.

CHE, T.; YAN, C.; TIAN, D.; ZHANG, X. et al. The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne), 12, p. 773646, 2021. Disponível em: 10.3389/fendo.2021.773646.

CIBIČKOVÁ, Ľ.; LANGOVÁ, K.; VAVERKOVÁ, H.; LUKEŠ, J. et al. Superior Role of Waist Circumference to Body-Mass Index in the Prediction of Cardiometabolic Risk in Dyslipidemic Patients. Physiol Res, 68, n. 6, p. 931-938, Dec 30 2019. Disponível em: 10.33549/physiolres.934176.

CLAUSEN, J. S. R.; MAROTT, J. L.; HOLTERMANN, A.; GYNTELBERG, F. et al. Midlife Cardiorespiratory Fitness and the Long-Term Risk of Mortality: 46 Years of Follow-Up. J Am Coll Cardiol, 72, n. 9, p. 987-995, Aug 28 2018. Disponível em: 10.1016/j.jacc.2018.06.045.

COOPER, K. H. A means of assessing maximal oxygen intake. Correlation between field and treadmill testing. JAMA, 203, n. 3, p. 201-204, Jan 15 1968.

COSTA, F. F. D.; MONTENEGRO, V. B.; LOPES, T. J. A.; COSTA, E. C. Combinação de fatores de risco relacionados à síndrome metabólica em militares da Marinha do Brasil. Arquivos Brasileiros de Cardiologia, 97, 2011. Disponível em: 10.1590/S0066-782X2011005000113.

DALLE-DONNE, I.; ROSSI, R.; GIUSTARINI, D.; MILZANI, A. et al. Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta, 329, n. 1-2, p. 23-38, Mar 2003. Disponível em: 10.1016/s0009-8981(03)00003-2.

DELGADO-FLOODY, P.; LATORRE-ROMÁN, P.; JEREZ-MAYORGA, D.; CAAMAÑO-NAVARRETE, F. et al. Feasibility of incorporating high-intensity interval training into physical education programs to improve body composition and cardiorespiratory capacity of overweight and obese children: A systematic review. J Exerc Sci Fit, 17, n. 2, p. 35-40, Jan 20 2019. Disponível em: 10.1016/j.jesf.2018.11.003.

DZIĘGIELEWSKA-GĘSIAK, S.; WYSOCKA, E.; FATYGA, E.; MUC-WIERZGOŃ, M. Relationship of SOD-1 Activity in Metabolic Syndrome and/or Frailty in Elderly Individuals. Metabolites, 14, n. 9, Sep 23 2024. Disponível em: 10.3390/metabo14090514.

EXÉRCITO, B. E. M. D. Diretriz para o Treinamento Físico Militar do Exército e sua Avaliação. 2008.

EXÉRCITO, B. E. M. D. Manual de Campanha EB-20-MC10.350 Treinamento Físico Militar. Manual de Campanha EB-20-MC10.350 Treinamento Físico Militar, 2015.

FAURE, P.; LAFOND, J.-L., 1995, Measurement of plasma sulfhydryl and carbonyl groups as a possible indicator of protein oxidation. In: Favier, A.E., Cadet, J., Kalyanaraman, B., Fontecave, M., Pierre, JL. (eds) Analysis of Free Radicals in Biological Systems. Birkhäuser Basel. Disponível em: 10.1007/978-3-0348-9074-8_17.

FEITOSA, A. D. M.; BARROSO, W. K. S.; MION JUNIOR, D.; NOBRE, F. et al. Brazilian Guidelines for In-office and Out-of-office Blood Pressure Measurement - 2023. Arq Bras Cardiol, 121, n. 4, p. e20240113, Feb 2024. Disponível em: 10.36660/abc.20240113.

FORTES, M. D. S. R.; ROSA, S. E. D.; COUTINHO, W.; NEVES, E. B. Epidemiological study of metabolic syndrome in Brazilian soldiers. Archives of Endocrinology and Metabolism, 63, 2019. Disponível em: 10.20945/2359-3997000000115.

FURRER, R.; HAWLEY, J. A.; HANDSCHIN, C. The molecular athlete: exercise physiology from mechanisms to medals. Physiol Rev, 103, n. 3, p. 1693-1787, Jul 01 2023. Disponível em: 10.1152/physrev.00017.2022.

GUEMBE, M. J.; FERNANDEZ-LAZARO, C. I.; SAYON-OREA, C.; TOLEDO, E. et al. Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort. Cardiovasc Diabetol, 19, n. 1, p. 195, Nov 22 2020. Disponível em: 10.1186/s12933-020-01166-6.

HERRMANN, F. R.; GRAF, C.; KARSEGARD, V. L.; MARESCHAL, J. et al. Running performance in a timed city run and body composition: A cross-sectional study in more than 3000 runners. Nutrition, 61, p. 1-7, May 2019. Disponível em: 10.1016/j.nut.2018.10.022.

JANAK, J. C.; PÉREZ, A.; ALAMGIR, H.; ORMAN, J. A. et al. U.S. military service and the prevalence of metabolic syndrome: Findings from a cross-sectional analysis of the Cooper Center Longitudinal Study, 1979-2013. Prev Med, 95, p. 52-58, Feb 2017. Disponível em: 10.1016/j.ypmed.2016.11.017.

KAWAMURA, T.; MURAOKA, I. Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint. Antioxidants (Basel), 7, n. 9, Sep 05 2018. Disponível em: 10.3390/antiox7090119..

KIM, C. H.; WHEATLEY, C. M.; BEHNIA, M.; JOHNSON, B. D. The Effect of Aging on Relationships between Lean Body Mass and VO2max in Rowers. PLoS One, 11, n. 8, p. e0160275, 2016. Disponível em: 10.1371/journal.pone.0160275.

KIM, H.; KANG, S.; GO, G. W. Exploring the multifaceted role of ginkgolides and bilobalide from. Food Sci Biotechnol, 33, n. 13, p. 2903-2917, Oct 2024. Disponível em: 10.1007/s10068-024-01656-3.

KUO, W. C.; BRATZKE, L. C.; OAKLEY, L. D.; KUO, F. et al. The association between psychological stress and metabolic syndrome: A systematic review and meta-analysis. Obes Rev, 20, n. 11, p. 1651-1664, Nov 2019. Disponível em: 10.1111/obr.12915.

LETNES, J. M.; NES, B. M.; WISLØFF, U. Age-related decline in peak oxygen uptake: Cross-sectional vs. longitudinal findings. A review. Int J Cardiol Cardiovasc Risk Prev, 16, p. 200171, Mar 2023. Disponível em: 10.1016/j.ijcrp.2023.200171.

MA, X.; CAO, Z.; ZHU, Z.; CHEN, X. et al. VO2max (VO2peak) in elite athletes under high-intensity interval training: A meta-analysis. Heliyon, 9, n. 6, p. e16663, 2023. DIsponível em: 10.1016/j.heliyon.2023.e16663.

MASENGA, S. K.; KABWE, L. S.; CHAKULYA, M.; KIRABO, A. Mechanisms of Oxidative Stress in Metabolic Syndrome. Int J Mol Sci, 24, n. 9, Apr 26 2023. Disponível em: 10.3390/ijms24097898.

MATHEW, A. V.; LI, L.; BYUN, J.; GUO, Y. et al. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care, 41, n. 11, p. 2431-2437, Nov 2018. Disponível em: 10.2337/dc18-0049.

MENGSTIE, M. A.; CHEKOL ABEBE, E.; BEHAILE TEKLEMARIAM, A.; TILAHUN MULU, A. et al. Endogenous advanced glycation end products in the pathogenesis of chronic diabetic complications. Front Mol Biosci, 9, p. 1002710, 2022. Disponível em: 10.3389/fmolb.2022.1002710.

MUNIZ-SANTOS, R.; FRANÇA, A.; JURISICA, I.; CAMERON, L. C. From Microcosm to Macrocosm: The -Omics, Multiomics, and Sportomics Approaches in Exercise and Sports. OMICS, 27(11):499-518, 2023. Disponível em: 10.1089/omi.2023.0169.

MYERS, J.; KOKKINOS, P.; NYELIN, E. Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome. Nutrients, 11, n. 7, Jul 19 2019. Disponível em: 10.3390/nu11071652.

OLIVEIRA, L. V. A.; SANTOS, B. N. S. D.; MACHADO, Í. E.; MALTA, D. C. et al. Prevalência da Síndrome Metabólica e seus componentes na população adulta brasileira. Ciência & Saúde Coletiva, 25, 2020. Disponível em: 10.1590/1413-812320202511.31202020.

OMURA, J. D.; BELLISSIMO, M. P.; WATSON, K. B.; LOUSTALOT, F. et al. Primary care providers' physical activity counseling and referral practices and barriers for cardiovascular disease prevention. Prev Med, 108, p. 115-122, Mar 2018. Disponível em: 10.1016/j.ypmed.2017.12.030.

PEKER, A.; AS, H.; KAYA, E.; BALCI, G. A. et al. The highest work rate associated with a predominantly aerobic contribution coincides with the highest work rate at which VO2max can be attained. Eur J Appl Physiol, 124(12):3527-3541, Jul 18 2024. Disponível em: 10.1007/s00421-024-05533-z

POWERS, S. K.; NELSON, W. B.; HUDSON, M. B. Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med, 51, n. 5, p. 942-950, Sep 01 2011. Disponível em: 10.1016/j.freeradbiomed.2010.12.009.

PRIETO-GONZÁLEZ, P.; SEDLACEK, J. Effects of Running-Specific Strength Training, Endurance Training, and Concurrent Training on Recreational Endurance Athletes' Performance and Selected Anthropometric Parameters. Int J Environ Res Public Health, 19, n. 17, Aug 29 2022. Disponível em: 10.3390/ijerph191710773.

PUCCI, G.; ALCIDI, R.; TAP, L.; BATTISTA, F. et al. Sex- and gender-related prevalence, cardiovascular risk and therapeutic approach in metabolic syndrome: A review of the literature. Pharmacol Res, 120, p. 34-42, Jun 2017. Disponível em: 10.1016/j.phrs.2017.03.008.

ROJO, M.; PÉREZ, H.; MILLÁN, A. L.; PAUTASSO, M. C. et al. Relationship of Mitochondrial DNA Oxidation and Content with Metabolic Syndrome and Cardiovascular Risk in Obesity Phenotypes. J Obes, 2024, p. 3008093, 2024. Disponível em: 10.1155/2024/3008093.

ROSA, G. Acute effect of concurrent training on hematological and hepatic profile, and muscle injury markers in trained individuals. Retos, 69, 690-698, 2025. Disponível em: 10.47197/retos.v69.110879.

ROSA, S. E. D.; LIPPERT, M. A.; MARSON, R. A.; FORTES, M. D. S. R. et al. Physical performance, body composition and metabolic syndrome in military personnel from the Brazilian army. Revista Brasileira de Medicina do Esporte, 24, 2018. Disponível em: 10.1590/1517-869220182406189325.

SALEM, M. Desenvolvimento e validação de equações e índices para a determinação da gordura corporal relativa, em militares brasileiros, a partir de medidas antropométricas. 2008. 104 f. (Doutorado em Saúde Pública) -, Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro.

SCRIBBANS, T. D.; VECSEY, S.; HANKINSON, P. B.; FOSTER, W. S. et al. The Effect of Training Intensity on VO 2max in Young Healthy Adults: A Meta-Regression and Meta-Analysis. Int J Exerc Sci, 9, n. 2, p. 230-247, 2016. Disponível em: 10.70252/HHBR9374.

SHERLING, D. H.; PERUMAREDDI, P.; HENNEKENS, C. H. Metabolic Syndrome. J Cardiovasc Pharmacol Ther, 22, n. 4, p. 365-367, Jul 2017. Disponível em: 10.1177/1074248416686187.

SIES, H. On the history of oxidative stress: Concept and some aspects of current development. Current Opinion in Toxicology, 7, p. 122-126, 2018. Disponível em: 10.1016/j.cotox.2018.01.002.

SILVA, V. S. D.; VIEIRA, M. F. S. International Society for the Advancement of Kinanthropometry (ISAK) Global: international accreditation scheme of the competent anthropometrist. Revista Brasileira de Cineantropometria & Desempenho Humano, 22, 2020. Disponível em: 10.1590/1980-0037.2020v22e70517.

SPAHIS, S.; BORYS, J. M.; LEVY, E. Metabolic Syndrome as a Multifaceted Risk Factor for Oxidative Stress. Antioxid Redox Signal, 26, n. 9, p. 445-461, Mar 20 2017. Disponível em: 10.1089/ars.2016.6756.

STEELS, E. L.; LEARMONTH, R. P.; WATSON, K. Stress tolerance and membrane lipid unsaturation in Saccharomyces cerevisiae grown aerobically or anaerobically. Microbiology (Reading), 140 ( Pt 3), p. 569-576, Mar 1994. Disponível em: 10.1099/00221287-140-3-569.

SUMINA NM. et al. Recomendações da Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial (SBPC/ML): Boas práticas em laboratório clínico. Editora Manole. 2020;(1):1-592.

VONA, R.; GAMBARDELLA, L.; CITTADINI, C.; STRAFACE, E. et al. Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases. Oxid Med Cell Longev, 2019, p. 8267234, 2019. Disponível em: 10.1155/2019/8267234.

WANG, Z.; CHEN, J.; ZHU, L.; JIAO, S. et al. Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study. BMC Cardiovasc Disord, 23, n. 1, p. 529, Oct 31 2023. Disponível em: 10.1186/s12872-023-03567-3.

WEDELL-NEERGAARD, A. S.; KROGH-MADSEN, R.; PETERSEN, G. L.; HANSEN, Å. et al. Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity. PLoS One, 13, n. 3, p. e0194991, 2018. Disponível em: 10.1371/journal.pone.0194991.

WEWEGE, M. A.; THOM, J. M.; RYE, K. A.; PARMENTER, B. J. Aerobic, resistance or combined training: A systematic review and meta-analysis of exercise to reduce cardiovascular risk in adults with metabolic syndrome. Atherosclerosis, 274, p. 162-171, Jul 2018. Disponível em: 10.1016/j.atherosclerosis.2018.05.002.

WIEBE, N.; STENVINKEL, P.; TONELLI, M. Associations of Chronic Inflammation, Insulin Resistance, and Severe Obesity With Mortality, Myocardial Infarction, Cancer, and Chronic Pulmonary Disease. JAMA Netw Open, 2, n. 8, p. e1910456, Aug 02 2019. Disponível em: 10.1001/jamanetworkopen.2019.10456.

WOOD, D. E.; SWAIN, D. P. Influence of Body Mass on Fitness Performance in Naval Special Warfare Operators. J Strength Cond Res, 35, n. 11, p. 3120-3127, Nov 01 2021. Disponível em: 10.1519/JSC.0000000000003249.

YARA, S.; LAVOIE, J. C.; LEVY, E. Oxidative stress and DNA methylation regulation in the metabolic syndrome. Epigenomics, 7, n. 2, p. 283-300, 2015. Disponível em: 10.2217/epi.14.84.

Interplay between Predictors of Metabolic Syndrome, Aerobic Fitness, and Oxidative Stress in Military Personnel of the Brazilian Army

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